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Graft integration was further evaluated macroscopically by observing the anastomotic sites for vascularization, tissue continuity, and the absence of lumen collapse or stenosis

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During mitochondrial biogenesis, the upstream signal regulators, silent information regulator 1 (SIRT1) and adenosine monophosphate-activated protein kinase (AMPK), activate PGC-1 through phosphorylation and deacetylation modifications

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