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FOR RESEARCH USE ONLY

Research published in Endocrinology demonstrated that this specific fragment contains the region responsible for growth hormones fat metabolism effects without the domains that bind to growth hormone receptors and trigger IGF-1 production, growth, and metabolic changes

In the animal models, inhibiting or knocking down NNMT improved markers tied to glucose handling and lowered cholesterol

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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)