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Without adequate B12, these processes begin to function sub-optimally and the effects, while not always dramatic in the early stages, accumulate in ways that many people experience as persistent tiredness, reduced mental sharpness, lower mood and a general lack of the vitality they feel they should have
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So, like, castration will undo some of the thymic involution
[DOI] [PubMed] [Google Scholar] Roseman M

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