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In addition, A deposition and excessive tau phosphorylation in the brains of AD patients can further inhibit the expression of SLC7A11, exacerbating GSH depletion and GPX4 inactivation, and forming a vicious cycle of oxidative stress-ferroptosis-AD pathological damage

Immunofluorescence (tissues) Tissue samples were fixed with 10% neutral-buffered formalin, embedded in paraffin, and cut into 4- to 5-m sections

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doi: 10.1016/j.ccell.2022.02.003 114 AlahdalMZhangHHuangRSunWDengZDuanLet al