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Endogenous thiamine levels increase in response to multiple stresses such as salinity or cold, possibly due to its need as a cofactor, as thiamine pyrophosphate is a required co-enzyme for several reactions of central metabolism

Wang D, Tang L, Wu Y, Fan C, Zhang S, Xiang B, et al

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As for the culture environment in vitro, where only AML cells are present, orid-liposome-MAL can non-competitively enter all AML cells, causing REDOX imbalance and exerting its anti-tumor effects
