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Phase 1 study dosing: Doses tested: 100 mcg to 1000 mcg daily Route: subcutaneous injection Results: dose-proportional effects on fat loss Safety: all doses well tolerated Phase 2 study dosing: Doses tested: 300 mcg to 600 mcg daily Route: once- or twice-daily subcutaneous injection Duration: 12 weeks typical Results: significant fat loss at all doses, with 500600 mcg showing the best efficacy Research Dosage Guidelines Based on available clinical data, research protocols generally consider the following ranges

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( B and C ) Longitudinal expression of GLUT1 and CD38 ( B ) and TMRM and MTDR levels ( C ) of pp65 495503 specific CD8 + T cells from controllers (blue, n = 6) and noncontrollers (red, n = 10)

Low B12 levels are associated with symptoms like: Fatigue or low energy Difficulty concentrating Numbness or tingling in hands and feet Swollen, inflamed tongue Dizziness or unsteadiness Muscle weakness Vision problems like blurriness or double vision What are the possible B12 injection side effects