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025039 discloses a method for preparing L-carnitine which includes ring opening and epoxidation of (S)-3-hydroxy-gamma-butyrolactone as a starting material, and a nu- cleophilic substitution with trimethylamine

Interestingly, methylation on arginine residues 210, 212, 787, 789 enhanced cytotoxicity and the authors proposed that this was as a consequence of mutual antagonism of phosphorylation (serines 215, 792) and arginine methylation (94)

Iran J Reprod Med 2012;10(2):7782

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36 Lifestyle, environment, and genetics are closely related to the occurrence and development of T2DM