homocysteine and glutathione synthesis Plasma Levels of Cysteine Increased in Pediatric NAFLD and Strongly Correlated with Severity of Liver Damage N-Acetyl-Cysteine supplementation lowers high homocysteine

The antiapoptotic genes bcl-XL and bcl-2 are overexpressed in quiescent leukemic progenitor cells

The ensuing demyelination can lead to subacute combined degeneration (SCD) in the spinal cord, resulting in loss of sensation of vibration and proprioception

New tools are becoming available for metabolic profiling studies including specific metabolic enzyme inhibitors, antibodies, and animal genetic models to elucidate the metabolic defects

LL-37 can be degraded by bacterial and host proteases, has demonstrated toxicity to host cells at high concentrations, and is costly to synthesize at scale

10.1016/j.neuroscience.2005.02.030 115 SubramanianN.NatarajanK.ClatworthyM