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This may function as a form of shutoff by preventing the activation of pro-inflammatory pathways such as NF-B and interferon responses, which are typically triggered by oxidative stress

Consequently, exposure to UV-A and UV-B, stimulates skin photoaging and can be responsible for the induction of skin cancer [6]

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J Biol Chem 265(25):1497114978 [PubMed] [Google Scholar] 13.Khalsa SS, Victor TA, Kuplicki R, Yeh HW, Vanover KE, Paulus MP, Davis RE (2022) Single doses of a highly selective inhibitor of phosphodiesterase 1 (lenrispodun) in healthy volunteers: a randomized pharmaco-fMRI clinical trial