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Although FASN inhibition can result in the accumulation of malonyl-CoA, a metabolic flux analysis using ethyl acetate-2- 13 C revealed that the direct elongation of LA (C18:2) to AA (C20:4) was not facilitated, suggesting that AA may be imported from the microenvironment 60

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Mahller YY, Vaikunth SS, Ripberger MC, Baird WH, Saeki Y, Cancelas JA, et al

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