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mitophagy can regulate mitochondrial homeostasis and reduce ROS production, thus exerting a certain anti-apoptotic and reduced necrotic cell death effects [102]

Statins, cholesterol-lowering drugs that inhibit HMG-CoA reductase, have also been investigated for metabolic targeting in NSCLC due to their effects on cholesterol biosynthesis and protein prenylation pathways impacting oncogenic signaling

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Once activated, GHR signal transduction is downregulated by suppressor of cytokine signaling proteins 13 (SOCS13)

DESeq2 was used for differential expression analysis, with significant gene expression differences defined by a Q value 2