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In preclinical models, Dihexa demonstrated superior pharmacokinetic properties, including good oral activity and effective BBB penetration, along with enhanced metabolic stability with a half-life of 335.5 minutes

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The beyond-use date for non-aqueous capsules prepared under compounding standards typically does not exceed 180 days, but pharmacists should assign shorter dating if stability studies or licensure requirements dictate

In addition to Minnesota, CMS has facilitated joint review processes in the Financial Alignment Initiative Demonstrations and has recently begun expanded use of joint review for the PACE