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2014 Jan;146(1):96-109.e1

International Journal of Biochemistry & Cell Biology 29 (5): 743751

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Additionally, when combined with B6 and folate, B12 has been shown to enhance blood-brain barrier function in patients experiencing mild cognitive impairment

Moreover, it has been recently proven that IGF-1 central administration also induced improvement in insulin sensitivity [291], meaning that this sudden rise after exercise or treatment could be of benefit not only in the periphery, but acting centrally
