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We have summarised the historical, clinical, epidemiological and experimental evidence accumulated over the last 60 years in the pre and postfortification eras, which consistently and substantially suggests that excess folate, in particular in folic acid users, can have direct harms to the nervous system, especially in the presence of vitamin B12 deficiency

Treatment Options for Vitamin B12 Deficiency If one is diagnosed with Vitamin B12 deficiency, several treatment methods can be taken depending on the cause and the advanced stage of the vitamin deficiency

The model identifies pathways responsible for the effect of the double and triple drug combinations, versus the effect of the addition of each single agent at its IC50 concentration

While studies have indicated a link between vitamin B12 and sleep regulation, the exact mechanism is not entirely understood
