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10.1016/j.bbagen.2017.10.007 Biochim
It is considered to be safe at therapeutic doses but it can induce a significant toxicity after overdose (Bessems and Vermeulen 2001)
the variability may be higher or lower in other regions of the brain
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Active site residues C46, A48, Q81, and W136 are highlighted and shown as sticks
