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In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

, Zhou, K

It has been observed that insulin resistance reduces mitochondrial respiration [56] and that human umbilical cord mesenchymal stromal cells from patients with GDM have premature senescence phenotypes and mitochondrial dysfunction

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