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Zhai H, Zhong S, Wu R, Mo Z, Zheng S, Xue J

Coschigano, K

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Since cysteine is a speed-limiting substrate for GSH biosynthesis, and GSH is the main antioxidant in mammalian cells, hindering intracellular cysteine and GSH levels can directly affect the activity of GPX4, which can easily induce ferroptosis