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21, 23 Consider supplementation when the patient is prescribed medications causing folate deficiency, e.g., methotrexate

Certain individuals are at a higher risk for B12 deficiencyincluding those following strict vegan or vegetarian diets, as well as patients with conditions that impair nutrient absorption, such as pernicious anemia, celiac disease, Crohns disease, or a history of gastrointestinal surgery

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This type of injection provide the advantage of better bioavailability by avoiding enzymes in the gastrointestinal tract

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