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Glutathione peroxidase 4 (GPX4) as a selenoperoxidase is a key upstream regulator of ferroptosis which plays two simultaneous roles, one in converting reduced GSH to glutathione disulfide (GSSG) and the other is to inhibit ferroptosis by reducing phospholipid hydroperoxides (PLOOHs) to the corresponding alcohols (PLOHs), thereby preventing the accumulation of lipid peroxides (Jiang et al., 2021)

Jiang Z, Wang T, Yuan S, Wang M, Qi W, Su R, He Z

Elite athletes, due to years of training, have already developed specific physiological adaptations

GSSG has a faint yellow color, while pure GSH is colorless

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (vcam-1) deficient mice