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Those with a severe deficiency may require a 5000 mcg dose

How long after starting vitamin B12 will I feel better

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Flowchart outlines process for diagnosing PA and Antibody Negative PA in UK BMJ B12 article bmj.com/content/349/bmj.g5226 Emphasises need to treat patients who are symptomatic even if their B12 level is within range

Your body might have B12 floating around in your bloodstream, but if it can't get inside the cells where the real work happens, you'll still experience the symptoms of a deficiency