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Impairment of the glutamate metabolic system may be one of the reasons for continuous memory loss and confusion in AD patients

Additionally, research by Yu et al (138) suggests that TSA alleviates cerebral ischemia-reperfusion injury by downregulating TGM2, inhibiting PANX1 expression and suppressing microglial activation and neuroinflammation (TNF-, IL-1 and IL-6), highlighting the multi-target regulation of TSA in the same disease

But heres where things get genuinely interesting: this isnt just theoretical biology anymore

Striatal Acetylcholine-Dopamine Imbalance in Parkinson Disease: In Vivo Neuroimaging Study with Dual-Tracer PET and Dopaminergic PET-Informed Correlational Tractography