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High extracellular concentrations of glutamate, another raw material for glutathione synthesis, can inhibit system ( SLC7A11 ) and induce iron-dependent non-apoptotic cell death, which may explain the toxic effect of excessive glutamate accumulation in the nervous system (Yang and Stockwell, 2016

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It is a devastating disease with a lack of effective treatments and although the cause of the neuronal death in ALS is not known, it is suspected that oxidative damage plays a key role