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Ayi, K., Cappadoro, M., Branca, M., Turrini, F

Interestingly, SFN restores the compromised mitochondrial membrane potential in PINK1-deficient cells and protects them against dopamine toxicity [484], suggesting that the role of Nrf2 in mitochondrial function [149, 174] may constitute part of the protective mechanism of pharmacological Nrf2 activators in Parkinson disease

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The samples were incubated at room temperature

For the confocal microscopy, PSCs were seeded onto 8-well chambered coverglass slides (Lab-TEK, NalgeNunc) at 5 10 3 cells per well, overnight, and incubated in DMEM (without serum) containing Au@PP/Cy5-siRNA or Au@PP/RA/Cy5-siRNA (4.2 M ATRA, 50 nM siRNA) at pH 6.5 or 7.4, respectively, for 2 h