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[DOI] [PubMed] [Google Scholar] 57.Hope M, Saxby TS

Although typically found in the caveolae of plasma membranes, proteomic analysis has demonstrated that in adipocytes caveolin-1 localizes to the lipid droplet as well (14, 23, 93, 103)

Overall, multiple mechanisms including inflammation and reduced FA re-esterification likely explain the impaired buffering capacity in adipocytes during obesity that leads to the spillover of FAs, buildup of toxic lipid metabolites and allosteric regulators that suppress insulin action and increased hepatic glucose output, respectively (Figure 5)

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