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10.1177/17590914221133236 100 LiuW.stbergN.YalcinkayaM.DouH.Endo-UmedaK.TangY.et al (2022b)

Cathepsin B-sensitive peptide linkers, hyaluronic acid-based nanoparticles, ATP-responsive liposomes and micelles, and 4-Phenylbutyric acid-modified hyaluronic acid-based nanoparticles are engineered to release pharmaceuticals in reaction to enzyme activity, enzymatic degradation by hyaluronidase, elevated ATP levels in metabolically active tumor cells, and esterase activity in 4-PBA-modified hyaluronic acid-based nanoparticles (79)

The thickness of human cartilaginous endplate (CEP) averages approximately 0.6 mm and is structurally akin to hyaline articular cartilage (Roberts et al., 1989)