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Other side effects Additional reported side effects include: Joint pain and water retention Muscle and joint aches Headaches and nausea Receptor desensitization with prolonged use Potential suppression of natural GH and IGF-1 production Who should avoid IGF-1 LR3 Certain groups should not use IGF-1 LR3: Anyone with active cancer or tumor history Those with severe insulin resistance or diabetes Pregnant or nursing women Anyone under 25 whose growth plates haven't closed Those with existing hormonal imbalances IGF-1 LR3 is not FDA-approved for general medical use and remains primarily a research compound

According to the paper, which was published in Science Translational Medicine, one of the clear-skinned participants ending up developing acne one week after receiving the vitamin B12 injection

While these injections may help some individuals with their weight loss, it's important to remember that they are not a standalone solution but rather a part of a comprehensive health strategy

The weekly standard is more established and is what the TRIUMPH program tests

So its important to pay attention to any symptoms -- which can grow slowly or pop up more quickly -- and to alert your doctor