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Some researchers inject near the pain site for local effects, while others use systemic administration

Mehrzadi et al., 2023)

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The therapeutic effects of FEE can be attributed to its hydroxycoumarin-rich composition, including isofraxidin, fraxetin, fraxinol, fraxidin, and their glycosylated derivatives, alongside lignans, flavonoids, polyphenols, and secoiridoids isolated from various Fraxinus species (23, 31, 68)

We hypothesize that endogenous H 2 S levels are correlated with inflammatory and clinical indices
