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Among them, digoxin and a PI3K inhibitor, alpelisib were confirmed and showed significant therapeutic effects in vivo in a mouse model of NASH
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It should be known that fibrates are in 6090% excreted renally, which limits their use in chronic kidney disease
The sequence encoding the SlpA 630- hDHFR-Strep Tag II signal peptide in pPOE002 was removed by inverse PCR site-directed mutagenesis with RF789 and RF790 to create pPOE011
