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Indeed, as discussed previously, some dietary antioxidants are located in the lipid-based cell membranes (e.g., vitamin E and carotenoids), whereas other dietary antioxidants are found in the aqueous phase (i.e., cytosol) of the cell (e.g., vitamin C) (Figure 2)
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HSP32/HO-1 is both necessary and sufficient for celastrol-mediated protection
