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Trans-right ventricle and transpulmonary metabolite gradients in human pulmonary arterial hypertension

All the images are part of the authors own work

After in situ mRNA hybridization of extruded germlines, both mpk-1ab and mpk-1b specific probes were low in the mitotic region, increased in the transition zone, and became abundant in the pachytene and oogenic regions (Figure 1D and 1E)

doi: 10.1007/s00592-018-1163-6 24 GibsonDASaundersPTKMcEwanIJ

This creates a vicious, self-perpetuating cycle: dysautonomia slows down the gut, the stagnant gut breeds bacteria that damage the intestinal barrier, and the resulting systemic inflammation further impairs the autonomic nervous system