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The levels of IL6 in the peripheral blood, ovaries, and FF in PCOS patients were higher than those in healthy control women ( Inflammatory cytokines IL-1 and IL-18 present in the ovarian tissue and FF in PCOS patients alter the follicular microenvironment by binding to receptors like IL-1R and TLR4 on the GCs, activating NF-B, which subsequently translocates into the nucleus ( These results suggested that the increased pro-inflammatory profile in the ovary and FF mediates apoptosis of GCs, leading to excessive follicle atresia

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Cannavo E, Sanchez A, Anand R, Ranjha L, Hugener J, Adam C, et al