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Macrophage apoE stimulates phospholipid and cholesterol efflux via ABCA1, and the apoE particles formed then promote cholesterol efflux through ABCG1, SR-BI, and aqueous diffusion (104,109-111)
This process is known as apoptosis
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When collagen-induction therapies dont create enough of a result, we can explore surgical removal of loose skin, through a tummy tuck
