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[DOI] [PMC free article] [PubMed] [Google Scholar] 388.Han YC, et al

"Repurposed drugs as adjunctive treatments for mania and bipolar depression: A meta-review and critical appraisal of meta-analyses of randomized placebo-controlled trials"

doi: 10.1016/j.neulet.2020.134919

If appetite suppression and other desired effects plateau at a lower dose, there is no requirement to keep escalating

Further studies highlight ALAs role in neuropathic pain reduction via BDNF-TrkB-ERK signaling [101] and sciatic nerve repair in compression injury models [121]
