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During flares, inflammatory cytokine levels spike, complement is consumed, and tissue damage accelerates

The results shown in Figure 4a demonstrate a significant effect of the combination treatment of vitamins B1, B6, and B12 in regard to synapsing on healthy cells when compared to untreated cells (4-fold increase

However, it is worth noting that another medication in the incretin-based therapy class metformin is well-established to reduce vitamin B12 absorption in some patients through effects on calcium-dependent ileal uptake mechanisms

Jungnik A, Arrubla Martinez J, Plum-Mrschel L, et al