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The coexistence of hypertension, endothelial dysfunction, platelet hyperactivity, and MetS contributes to the advancement of organ damage
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3.5.2 Methotrexate-induced renal injury Methotrexate (MTX), a potent anti-metabolite and folate antagonist, is administered at elevated doses for the treatment of various cancers, while lower doses are utilized for managing non-malignant conditions ( 3.5.3 Doxorubicin-induced renal intoxication Doxorubicin (DOX), a chemotherapeutic agent classified as an anthracycline, is a highly effective therapeutic used in the management of various hematological cancers and solid tumors (Tangpong et al., 2011)
In contrast, secondary or clinical frailty which is associated with known disability and/or comorbidity (ie, CVDs, NDs, CKD, T2D) 77 could significantly increase the generation of RONS products
Sorbitan Stearate is an emulsifier made by reacting sorbitol with stearic acid
