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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

Lipid peroxidation inhibitors: Long non-coding RNA H19 promotes ferroptosis in brain microvascular endothelial cells by regulating the miR-106b-5p/ACSL4 axis

It was speculated that all these changes in mutant variant dcmL121A/T146R may contribute to the increase in catalytic activity

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