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Annu Rev Physiol 81:235259

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Abstract Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors

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Although one might consider dysfunctional pelvic floor musculature to be a confusable disorder such as overactive bladder, its clinical significance as a generator of pain and voiding symptoms in the majority of IC/BPS patients was felt to merit its position as a distinct clinical phenotype