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As a result, intracellular NAD+ levels increase, enhancing the activity of NAD+-dependent enzymes such as sirtuins and poly(ADP-ribose) polymerases (PARPs)

*New patients require an initial consultation to review health history and ensure appropriate dosing and candidacy

This conservative approach minimizes copper toxicity risk but may require 16+ weeks to produce observable density changes

Not a medicine, not evaluated by BPOM, and not for human or veterinary consumption

Researchers considering extended protocols should be aware that this safety gap exists and should monitor for unexpected effects in tissues where NNMT has normal physiological functions