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MTX-induced ER stress occurs predominantly through the PERK/CHOP-10 pathway (Koo et al., 2016) (Figure 1)
revealed that inhibiting autophagy with chloroquine or ATG5/ATG7 siRNAs significantly enhanced EGFR-TKI-induced cytotoxicity in NSCLC cells (Han et al

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BBB also provides protection to neural tissues against toxins and pathogens which may be present in circulation
