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The quality and integrity of the isolated RNA was monitored by QIAxcel analysis according to the manufacturers instructions

Not for human therapeutic use.

However, a direct comparison of these results was not possible due to a lack of congruence between the (a) age groups investigated, namely, clear-cut young and old groups (MRS (Emir et al., 2011, Hupfeld et al., 2021)) versus young + middle-aged and old groups (biochemical assay (Tong et al., 2016)), and/or (b) specific ROIs used: medial frontal (Hupfeld et al., 2021) versus prefrontal dorsolateral cortex (Tong et al., 2016), and occipital cortex (Emir et al., 2011) versus primary visual cortex (Tong et al., 2016)
As defined by Arthur Riggs and colleagues, it is "the study of mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence." [21] The term has also been used, however, to describe processes which have not been demonstrated to be heritable, such as some forms of histone modification
