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4.2 Colitis/IBD Inflammatory bowel disease is characterized by damage to the intestinal epithelial barrier resulting in increased permeability and the resultant dissemination of the commensal microbiota

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Where semaglutide and tirzepatide work through incretin pathways, cagrilintide targets amylin receptors in the brain to reduce appetite and slow gastric emptying through an entirely separate signaling cascade

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