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10.3390/metabo2020303 Metabolites

Biol Psychiatry 45:16461652 Okatani Y, Wakatsuki A, Reiter RJ, Miyahara Y (2002) Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin

doi: 10.1351/pac197333010145

Dosagens nos estudos animais: Na grande maioria dos estudos pr-clnicos, as doses utilizadas em ratos situam-se entre 10 g/kg e 10 ng/kg de peso corporal, administradas por via intraperitoneal ou oral

Rate constants for mammalian glutaredoxins and poplar GrxS12 range from 2.5 10 4 to 2 10 6 M 1 s 1 and also support a rate-limiting reductive half-reaction 19,20,21,37