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The magnitude of the potassium rise in the extracellular space increases with injury severity (Katayama et al., 1990), with as much as a fivefold increase observed at 1.5 minutes post injury

2) is widely accepted, and several inducers of this type of erythrocyte death have been described, including the antiinflammatory compounds Bay 11-7082, parthenolide, and dimethyl fumarate [113], H 2 O 2 [114], the food additive E407a (semi-refined carrageenan) [115], and the tricyclic antidepressant desipramine [116]

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During severe COPD, oxidative stress has been found to be exacerbated and GSH levels further depleted
