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Taken together, these studies have strongly suggested that DPRs play a central role in the pathogenesis of C9-ALS/FTD

Malhotra J, Nguyen D, Tan T, Semeniuk Iii GB

This microbial LPS can directly translocate to the brain, where it activates microglia through the TLR4/NF-B pathway, promoting type I interferon signaling while suppressing type II interferon-driven autoimmune responses, thereby influencing susceptibility to autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) [1, 287]

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Behavioral approaches Cognitive behavioral therapy, mindful eating programs, and structured support groups can address the psychological components of postpartum weight retention