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Description
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Transporter Reversal as a Survival Exit Valve

Fundamentals of Pathology: Medical Course and Step 1 Review

Cp deficiency and mutations in copper-transporting genes such as ATP7B can cause abnormal metal distribution in the brain and induce (or exacerbate) neurodegenerative processes, including PD (168)

It upregulates the expression of various genes involved in iron and ROS metabolism, such as NQO1, HO1, and FTH1, through the p62-Keap1-NRF2 pathway, inhibiting cellular ferroptosis [62]
