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(Peer-reviewed Review)
Key Takeaways: 1
In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)
In tumor cells, p53 has been well characterized as a promoter of ferroptosis through suppression of SLC7A11 expression and subsequent inhibition of cystine uptake
J Comp Neurol (1990) 291:17994.10.1002/cne.902910203 95 StrittmatterSMThieleEAKapiloffMSSnyderSH
