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GH was also found to promote an increase in mitochondrial oxidative capacity and abundance of several mitochondrial genes when acutely administered (209) while exogenous administration of IGF-1 was associated with a reduced susceptibility of dystrophic muscles to contraction-induced injury (210)

CYP3A4 mediated N-demethylation to norhydrocodone is the primary metabolic pathway of hydrocodone with a lower contribution from CYP2D6 mediated O-demethylation to hydromorphone

[DOI] [PMC free article] [PubMed] [Google Scholar] 448.Lee C., Ahn J.-W., Kim J.-B., Kim J.Y., Choi Y.-E

Zhou et al., 2022 and AChE activity (Olofinnade et al., 2021)