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"Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis"

We recently found that ccz-1(-) mutants lack gut granules, whereas rab-7(-) mutants have only a minor defect in gut granule protein localization, and sand-1 is dispensable for gut granule biogenesis [19]

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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11