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Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation

Yoshimaru, T

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KEAP1 has highly reactive thiol groups that act as a sensor for the NRF2 inducers.4 The cysteine residue (Cys151) in the KEAP1-BTB domain is essential for NRF2 activation,5 while Cys288 and Cys297 are crucial for the suppression of NRF2 activity.6 The Kelch domain of KEAP1 mediates the binding of the Neh2 domain to NRF2 and thereby negatively regulates NRF2 transactivation

In particular, Liposomal Glutathione uses a unique delivery system that protects the active ingredient, potentially enhancing its bioavailability compared to traditional forms