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In conclusion, while the current clinical evidence is not yet sufficient, the safety and preliminary efficacy of hydrogen suggest that it may serve as a potential adjunct therapy that warrants further validation in future clinical studies

Abstract Swertiamarin, a predominant iridoid glycoside from hepatoprotective Swertia herbs, is biotransformed in vivo into nitrogen-containing metabolites ( R )-gentiandiol and ( S )-gentiandiol

Importantly, the combination of BHMT and MS activities in the liver allow the maintenance of the physiological concentration of Hcy, which is in equilibrium with SAH due to the reversibility of the SAHH enzyme

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